Agenus
Develops investigational BOT+BAL antibodies for colorectal cancer and selected tumors.
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Profile
Develops BOT+BAL, an investigational anti-CTLA-4 and anti-PD-1 antibody combination for colorectal cancer and selected tumors. The clinical-stage immuno-oncology company combines internal development capabilities with selected collaborations and retained manufacturing capacity.
Develops BOT+BAL, an investigational combination of botensilimab, an anti-CTLA-4 antibody, and balstilimab, an anti-PD-1 antibody. The lead program is being developed for colorectal cancer and selected other tumors; neither component is approved for commercial sale.
Discovery and development combine internal translational, clinical, and regulatory work with selected collaborations. Earlier vaccine, adjuvant, and checkpoint-antibody programs inform a portfolio that the company narrowed after its strategic realignment.
Manufacturing flexibility depends on the Zydus collaboration, which provides committed capacity at transferred U.S. biologics facilities. Progress toward registration and commercialization depends on additional capital and regulatory development.
Company facts
Key statistics
Year to date +137% · Average volume (30d) 1.6M
Analysts
Ratings
Target range
Latest analyst notes
| Date | Firm | Action | Prior rating | Rating | Prior target | Target |
|---|---|---|---|---|---|---|
| Aug 11, 2026 | H.C. Wainwright | Reiterate | Buy | $7 | $25 | |
| Jun 4, 2025 | H.C. Wainwright | Upgrade | Neutral | Buy | ||
| Jun 4, 2025 | HC Wainwright & Co. | Upgrade | Neutral | Buy |
Earnings
EPS
Revenue
History
| Report date | EPS est | EPS | Surprise | Revenue est | Revenue | Surprise | Next session |
|---|---|---|---|---|---|---|---|
| Aug 6, 2026Q2 FY26 | $0.05 | −$0.01 | −122.2% | $34.0M | $34.5M | +1.5% | −3.73% |
| May 11, 2026Q1 FY26 | $2.10 | $1.02 | −51.4% | $129.5M | $33.7M | −74.0% | +5.52% |
| Mar 16, 2026Q4 FY25 | −$1.27 | $0.56 | +144.1% | $28.1M | $34.2M | +21.7% | +21.28% |
| Nov 10, 2025Q3 FY25 | $2.63 | $1.94 | −26.2% | $28.1M | $30.2M | +7.6% | +1.43% |
Financial highlights
| 12 quarters | Q1 FY25 | Q2 FY25 | Q3 FY25 | Q4 FY25 | Q1 FY26 | Q2 FY26 | |
|---|---|---|---|---|---|---|---|
| Revenue | $24.1M | $25.7M | $30.2M | $34.2M | $33.7M | $34.5M | |
| Gross profit | $2.4M | −$1.3M | $6.0M | $26.7M | $33.2M | $34.5M | |
| Operating income | −$13.3M | −$16.7M | −$4.5M | $14.4M | $15.1M | $11.3M | |
| Net income | −$25.3M | −$28.0M | $63.9M | −$10.6M | $39.2M | −$550.0K | |
| Diluted EPS | −$1.03 | −$1.00 | $1.94 | −$0.30 | $1.02 | −$0.01 | |
| Gross margin | 10.0% | -4.9% | 19.8% | 78.0% | 98.3% | 100.0% | |
| Operating margin | -55.3% | -65.0% | -15.0% | 42.1% | 44.6% | 32.7% |
Fiscal years (4-quarter sums)FY21 $295.7M · FY22 $98.0M · FY23 $156.3M · FY24 $103.5M · FY25 $114.2M
Revenue by product · Q2 FY26
Revenue by geography · Q2 FY26
Balance sheet, Jun 30, 2026Cash & short-term investments $18.7M · Total debt $40.7M · Total assets $172.7M · Shareholders' equity −$199.1M
Dividends
No dividends on record.
Ownership
Shares outstanding 41.64M · Float 37.19M · 89.3% free float
Top shareholders13F · 13D/G · Form 4
| Holder | Shares | % outstanding | Form | Filed |
|---|---|---|---|---|
| RA Capital Management, L.P. | 4.34M | 9.90% | 13G | Jul 20, 2026 |
| Invus Public Equities, L.P. | 3.97M | 8.80% | 13G | Jul 17, 2026 |
| BlackRock, Inc. | 2.51M | 6.00% | 13G | Jul 27, 2026 |
| Zynext Ventures USA LLC | 2.13M | 5.90% | 13D | Jan 23, 2026 |
| Vanguard Capital Management LLC | 1.68M | 4.02% | 13F | Aug 13, 2026 |
Insider tradesForm 4
No open-market trades in the last 12 months.
View detailsPeers
- Bristol-Myers Squibb
Approved PD-1 plus CTLA-4 regimen across major solid tumors
- Adagene (ADR)
Masked anti-CTLA-4 doublet in MSS metastatic colorectal cancer
- Merck
Approved PD-1 therapy for MSI-H/dMMR metastatic colorectal cancer
- BioNTech (ADR)
Late-stage CTLA-4 candidate for solid-tumor immunotherapy
- MacroGenics
Phase 2 PD-1×CTLA-4 bispecific under a partial clinical hold
CompareAfter-hours close
| Company | Price | Change | |||||
|---|---|---|---|---|---|---|---|
| Agenus | $7.66 | 0.00% | $319.0M | 2.9 | — | 2.4 | +34.3% |
| Bristol-Myers Squibb | $66.60 | +0.05% | $136.00B | 14.7 | 10.5 | 2.8 | +5.7% |
| Adagene (ADR) | $3.68 | +0.55% | $138.5M | — | — | 14.9 | — |
| Merck | $148.19 | −0.08% | $366.18B | 118.7 | 17.2 | 5.5 | +5.1% |
| BioNTech (ADR) | $102.50 | +0.40% | $25.64B | — | — | 8.4 | −60.7% |
| MacroGenics | $4.10 | −0.97% | $262.5M | — | — | 1.6 | +47.6% |
| Median | 66.7 | 13.8 | 5.5 | +5.4% |







