AMZNprintsminutestrendsdividendsdrawdownsP/E 28.4macronarrativesvolatilitybuybackssentiment+0.8%marginsMSFTPMI 52.1momentumdividendsflowsPMI 52.1digeststhreadsvolatilityearnings callsvolumesβ 1.24breakoutsnewsflow2s10sliquidityheadlines−1.2%breakoutsnoiseGOOGLbuybacksrevisionstrendsPMI 52.1briefstickersnoiseGDPsentimentchattertranscriptsGOOGLsentimentvolatilitybuybacksMSFTwhispersMETAsessionsyield curves13FfuturesdowngradesPMI 52.1headlinesthe tapeflowsdowngradesfutures+0.8%earnings callstranscriptsclosesgammacatalystsrevisionsvolatilitysentimentchatter+2.41%earnings callssentimentfilingstrends10y 4.21%cyclesbuybackswiresspx 0dtewhisperstickersQ3trendsnewsflowearnings callsWTI 78.2sentimentnoisethreadsrumorsnarrativesFOMCconsensusestimatesmomentumYoY +18%tickersmomentumprintsβ 1.24revisions

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PCEliquiditysentimentbreakoutsdowngradesP/E 28.4threadsAAPLSPXvolatilityNDXflowscyclesliquidityestimatesEPS 4.12

Earnings are out

ANAB · NASDAQ · Biotechnology

AnaptysBio (ANAB)

Manages Jemperli and imsidolimab royalties through GSK and Vanda partnerships.

$55.86

At close+0.57 (+1.04%)

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Breakdown13F · 13D/G · Form 4

Institutions220 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail	≈ 103.35%	30.07M shares
Insiders12 holders · as of Jun 17, 2026	13.25%	3.85M shares
Adds to	116.60%

29.10M company shares as of Sep 3, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.

A stock split fell inside the quarter, so quarter-on-quarter changes are not shown.

These groups come from separate filings that can overlap, so they add to 116.60%; nothing is left for Other.

Top shareholders13F · 13D/G · Form 4

Holder	Stake	Shares	Evidence
EcoR1 Capital, LLCInstitution	27.08%	7.88M	13Fas of Jun 30, 2026
James N. Topper¹Insiderdirector	9.88%	2.88M	13Gfiled May 6, 2024 ↗
Sirenia Capital Management LPInstitution	6.60%	1.92M	13Gfiled May 15, 2026 ↗
BlackRock, Inc.Institution	6.34%	1.84M	13Fas of Jun 30, 2026
Tang Capital Management LLCInstitution	4.57%	1.33M	13Fas of Jun 30, 2026
State Street CorpInstitution	4.42%	1.29M	13Fas of Jun 30, 2026
Vanguard Capital Management LLCInstitution	3.11%	906,233	13Fas of Jun 30, 2026
Affinity Asset Advisors, LLCInstitution	2.84%	826,109	13Fas of Jun 30, 2026
SanofiInstitution	2.82%	821,917	13Fas of Jun 30, 2026
Millennium Management LLCInstitution	2.77%	807,316	13Fas of Jun 30, 2026
Daniel FagaInsiderdirector, officer: President, CEO	2.56%	743,948	Form 4filed Mar 27, 2026 ↗
Woodline Partners LPInstitution	2.46%	717,014	13Fas of Jun 30, 2026
683 Capital Management, LLCInstitution	2.27%	660,000	13Fas of Jun 30, 2026
Geode Capital Management, LLCInstitution	2.19%	637,873	13Fas of Jun 30, 2026
Palo Alto Investors LPInstitution	2.07%	603,489	13Fas of Jun 30, 2026
Goldman Sachs Group IncInstitution	2.01%	584,070	13Fas of Jun 30, 2026
First Light Asset Management, LLCInstitution	2.00%	582,004	13Fas of Jun 30, 2026
D. E. Shaw & Co., Inc.Institution	1.85%	539,666	13Fas of Jun 30, 2026
Vanguard Portfolio Management LLCInstitution	1.81%	527,858	13Fas of Jun 30, 2026
Apis Capital Advisors, LLCInstitution	1.71%	497,000	13Fas of Jun 30, 2026
Sofinnova Investments, Inc.Institution	1.70%	493,536	13Fas of Jun 30, 2026
Arrowstreet Capital, Limited PartnershipInstitution	1.68%	488,651	13Fas of Jun 30, 2026
Nuveen, LLCInstitution	1.45%	420,664	13Fas of Jun 30, 2026
Bank of America Corp /DE/Institution	1.44%	417,812	13Fas of Jun 30, 2026
Citadel Advisors LLCInstitution	1.36%	394,373	13Fas of Jun 30, 2026

James N. Topper's transaction reports restate only vehicles that traded; the 2024 ownership statement (2.88M) is used instead.

13F — a manager's quarterly holdings · 13D/13G — an ownership statement filed at 5% or more · Form 4 — an insider's transaction report

Institutions13F, as of Jun 30, 2026

220 holders · 30.07M shares

Holder	Shares	% outstanding	Filed
Ecor1 Capital, LLC	7.88M	27.08%	Aug 14, 2026
BlackRock, Inc.	1.84M	6.34%	Aug 7, 2026
Tang Capital Management LLC	1.33M	4.57%	Aug 14, 2026
State Street Corp	1.29M	4.42%	Aug 7, 2026
Vanguard Capital Management LLC	906.2K	3.11%	Aug 13, 2026
Affinity Asset Advisors, LLC	826.1K	2.84%	Aug 13, 2026
Sanofi	821.9K	2.82%	Jul 28, 2026
Millennium Management LLC	807.3K	2.77%	Aug 14, 2026

Ownership statements13D/G · 5% or more, as filed

Holder	% of class	Shares	Form	Filed
Sirenia Capital Management LP	6.70%	1.92M	13G	May 15, 2026 ↗
BlackRock, Inc.	6.20%		13G	Apr 17, 2025 ↗

Insider tradesForm 4

Latest trades

Date	Insider	Type	Shares	Avg price	Owned after
Mar 30, 2026	John P. Schmiddirector	Sale · 3 lots	20,645	$56.11	31,622
Mar 27, 2026	Daniel Fagadirector, officer: President, CEO	Sale · 10 lots	17,679	$61.61	495,965
Feb 11, 2026	Eric J. Loumeauofficer: CHIEF LEGAL OFFICER	Sale	10,000	$54.00	12,835
Jan 15, 2026	Magda Marquetdirector	Sale · 2 lots	11,000	$48.23	9,930
Jan 8, 2026	Daniel Fagadirector, officer: President, CEO	Sale	14,281	$44.71	479,344
Jan 8, 2026	Eric J. Loumeauofficer: CHIEF LEGAL OFFICER	Sale	2,210	$44.71	12,835
Jan 8, 2026	Dennis Mulroyofficer: CHIEF FINANCIAL OFFICER	Sale	2,515	$44.71	21,852
Jan 8, 2026	Paul F. Lizzulofficer: Chief Medical Officer	Sale	3,650	$44.71	42,088
Jan 7, 2026	Dennis Mulroyofficer: CHIEF FINANCIAL OFFICER	Sale	1,908	$45.11	17,667
Jan 7, 2026	Daniel Fagadirector, officer: President, CEO	Sale	9,202	$45.11	466,787

CongressHouse and Senate disclosures

Not reported.