Faeth Therapeutics
Develops PIKTOR, an oral cancer regimen designed to block multiple PAM-pathway nodes.
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Profile
Develops PIKTOR, an investigational oral cancer regimen combining serabelisib and sapanisertib, while advancing preclinical NEAAR and IEM programs. With no product revenue or commercial sales organization, its model finances clinical development while relying on licensed rights and external research, trial, and manufacturing partners.
Develops cancer therapeutics around PIKTOR, an investigational oral combination of serabelisib and sapanisertib that targets several points in the PI3K/AKT/mTOR pathway. Its clinical programs study PIKTOR in advanced endometrial cancer and HR-positive/HER2-negative advanced breast cancer; its earlier work includes the preclinical NEAAR and IEM programs. Based in Austin, Texas, it has development rights for PIKTOR components worldwide within licensed fields.
Runs a focused, pre-revenue development model, relying on CROs, clinical sites, consultants, suppliers, and contract manufacturers rather than a commercial sales organization. Progress depends on clinical evidence, regulatory approval, reliable supply of both active ingredients, licensed rights from Takeda and Millennium Takeda, and external execution.
Company facts
Key statistics
Year to date +249% · Average volume (30d) 299.4K
Analysts
Ratings
Target range
Latest analyst notes
| Date | Firm | Action | Rating | Target |
|---|---|---|---|---|
| Aug 21, 2026 | Needham | Initiate | Buy | $56 |
| Jul 31, 2026 | Raymond James | Initiate | Outperform | $56 |
| Jul 27, 2026 | Oppenheimer | Initiate | Outperform | $60 |
| Jul 20, 2026 | Citigroup | Initiate | Outperform | |
| Jun 25, 2026 | Robert W. Baird | Target | $57 |
Earnings
EPS
Revenue
History
| Report date | EPS est | EPS | Surprise | Revenue est | Revenue | Surprise | Next session |
|---|---|---|---|---|---|---|---|
| Aug 4, 2026Q2 FY26 | −$2.64 | −$2.84 | −7.6% | — | — | — | −6.73% |
| May 15, 2026Q1 FY26 | −$0.62 | −$131.45 | −21,101.6% | — | — | — | −2.55% |
| Mar 30, 2026Q4 FY25 | −$4.81 | −$3.74 | +22.2% | — | — | — | +25.43% |
| Nov 14, 2025Q3 FY25 | −$4.11 | −$3.62 | +11.9% | — | −$4.9M | — | +1.62% |
Financial highlights
| 11 quarters | Q1 FY25 | Q2 FY25 | Q3 FY25 | Q4 FY25 | Q1 FY26 | Q2 FY26 | |
|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | −$4.9M | $0 | $0 | $0 | |
| Gross profit | $0 | $0 | $0 | $0 | −$133.0M | $0 | |
| Operating income | −$7.3M | −$5.2M | −$4.9M | −$5.0M | −$170.6M | −$18.4M | |
| Net income | −$6.9M | −$4.9M | −$4.6M | −$4.7M | −$170.2M | −$16.0M | |
| Diluted EPS | −$5.45 | −$3.91 | −$3.62 | −$3.74 | −$131.45 | −$2.84 | |
| Gross margin | — | — | — | — | — | — | |
| Operating margin | — | — | — | — | — | — |
Fiscal years (4-quarter sums)FY24 $0 · FY25 −$4.9M
Balance sheet, Jun 30, 2026Cash & short-term investments $186.4M · Total debt $592.0K · Total assets $189.3M · Shareholders' equity $173.0M
Dividends
No dividends on record.
Ownership
Shares outstanding 25.78M · Float 18.61M
This issuer lists more than one class and the share count spans them all, so a stake here reads as a share of the whole company, not of this class.
Top shareholders13F · 13D/G · Form 4
| Holder | Shares | % of company | Form | Filed |
|---|---|---|---|---|
| S2G Investments, LLC | 2.58M | 9.99% of class | 13G | Jun 23, 2026 |
| Suvretta Capital Management, LLC | 2.02M | 7.80% of class | 13G | Jun 23, 2026 |
| Khosla Ventures VI, LP | 1.64M | 6.40% of class | 13G | Aug 14, 2026 |
Insider tradesForm 4
Nothing filed in the last 12 months.
View detailsPeers
- Celcuity
Approved multi-node pathway regimen in advanced HR+/HER2- breast cancer.
- Novartis (ADR)
Approved PI3K-alpha and mTOR options in advanced HR+/HER2- breast cancer.
- AstraZeneca (ADR)
Approved AKT therapy for biomarker-selected HR+/HER2- breast cancer.
- Relay Therapeutics
Phase 3 PI3K-alpha program for PIK3CA-mutant HR+/HER2- breast cancer.
- Eli Lilly
Phase 3 PI3K-alpha program for PIK3CA-mutant HR+/HER2- breast cancer.
- OnKure Therapeutics
Early PI3K-alpha program in metastatic breast cancer.
CompareAfter-hours close
| Company | Price | Change | |||||
|---|---|---|---|---|---|---|---|
| Faeth Therapeutics | $33.84 | +0.48% | $872.4M | — | — | — | — |
| Celcuity | $90.10 | +1.81% | $4.31B | — | — | — | — |
| Novartis (ADR) | $153.81 | 0.00% | $292.35B | 23.2 | 16.4 | 5.3 | +0.9% |
| AstraZeneca (ADR) | $161.79 | −0.55% | $252.33B | 24.4 | 15.2 | 4.1 | +6.4% |
| Relay Therapeutics | $19.10 | +1.82% | $4.11B | — | — | 397.4 | −48.3% |
| Eli Lilly | $1,173.00 | −0.08% | $1.10T | 39.4 | 28.7 | 13.9 | +47.7% |
| OnKure Therapeutics | $3.79 | 0.00% | $153.5M | — | — | — | — |
| Median | 24.4 | 16.4 | 9.6 | +3.7% |








