GPCR · NASDAQ · Biotechnology

Structure Therapeutics (ADR)

Develops oral small-molecule medicines for metabolic, cardiovascular, and pulmonary conditions.

$47.37
After-hours close−0.10 (−0.21%)
At close$47.47(−3.56%)

Breakdown13F · Form 4

Institutions 115.89%Insiders

Shares outstanding 57.57M · Float 54.73M · 95.1% free float

Insiders — filings are in the shares behind the receipt.

This listing is a depositary receipt and the Form 4 positions here are filed in the shares behind it, a different unit from the share count and in a ratio the filings never state, so no insider percentage is shown.

Top shareholders13F · 13D/G · Form 4

HolderShares% outstandingFormFiled
FMR LLC8.40M14.60%13FMay 15, 2026
Wellington Management Group LLP7.26M12.61%13FMay 15, 2026
Avoro Capital Advisors LLC6.56M11.39%13FMay 15, 2026
Janus Henderson Group PLC5.35M9.30%13FMay 18, 2026
Deep Track Capital, LP4.28M7.43%13FMay 15, 2026

Institutions13F, as of Mar 31, 2026

209 holders · 66.72M shares · 39 new positions · 109 increased · 63 reduced · 39 closed

HolderShares% outstandingChg q/qFiled
FMR LLC8.40M14.60%−308.8KMay 15, 2026
Wellington Management Group LLP7.26M12.61%+138.3KMay 15, 2026
Avoro Capital Advisors LLC6.56M11.39%0May 15, 2026
Janus Henderson Group PLC5.35M9.30%+264.8KMay 18, 2026
Deep Track Capital, LP4.28M7.43%+168.1KMay 15, 2026
BVF Inc/IL3.46M6.01%−19.7KMay 15, 2026
Morgan Stanley2.31M4.00%+217.6KMay 15, 2026
Price T Rowe Associates Inc /MD/2.00M3.48%+329.6KMay 15, 2026

Beneficial owners13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
FMR LLC15.00%31.11M13GFeb 5, 2026
Wellington Management Group LLP10.10%21.37M13GFeb 10, 2026
Avoro Capital Advisors LLC9.38%16.22M13GNov 14, 2025
Janus Henderson Group PLC7.70%4.45M13GNov 14, 2025
Ein #6.90%3.96MNov 14, 2024
Deep Track Capital, LP5.95%12.34M13GFeb 13, 2026

InsidersForm 4

InsiderRoleSharesFiled
Raymond C. Stevensdirector, officer: CHIEF EXECUTIVE OFFICER5.8KMar 5, 2026
Jun Yoonofficer: CHIEF FINANCIAL OFFICER2.9KJul 3, 2025
FMR LLC10 percent owner, other: See Remark 11.4KJul 24, 2026
Crespo Blas Collofficer: CHIEF MEDICAL OFFICER1.2KJul 3, 2025
Ashley Hallofficer: Chief Development Officer462Mar 5, 2026

1 ten-percent owner holds 1.4K shares by Form 4 — the 13D/G table above shows that stake, the figure above counts officers and directors only · 3 people have not refiled in the last 18 months (277.5K shares), so they are not in the figure above · 13 positions are filed in the unlisted share unit (9.50M shares), which no share count here divides

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Aug 18, 2026
Xichen Linofficer: CHIEF SCIENTIFIC OFFICER
Sale · 3 lots3,9390
Aug 4, 2026
Xichen Linofficer: CHIEF SCIENTIFIC OFFICER
Sale · 2 lots3,9390
Jul 22, 2026
FMR LLC10 percent owner, other: See Remark 1
Sale · 2 lots17,4521,369
Jul 14, 2026
Xichen Linofficer: CHIEF SCIENTIFIC OFFICER
Sale · 2 lots7,8780
Jun 25, 2026
Xichen Linofficer: CHIEF SCIENTIFIC OFFICER
Sale7,8780
Apr 14, 2026
FMR LLC10 percent owner, other: See Remark 1
Sale · 2 lots17,4522,736
Jan 15, 2026
FMR LLC10 percent owner, other: See Remark 1
Sale · 8 lots17,4524,103
Dec 8, 2025
FMR LLC10 percent owner, other: See Remark 1
Sale · 10 lots52,3560

CongressHouse and Senate disclosures

Not reported.