Praxis Precision Medicines
Develops small-molecule and antisense therapies for essential tremor and genetic epilepsies.
$344.75
After-hours close−0.38 (−0.11%)
At close$345.13(−6.18%)
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Breakdown13F · Form 4
Institutions 153.59%Insiders 0.68%
A 13F quarter can total more than the shares outstanding — sub-advisers file the same block twice, and a filer's own share count can be a quarter stale. No split is drawn from it.
Shares outstanding 27.88M · Float 26.12M · 93.7% free float
Institutions13F, as of Jun 30, 2026
329 holders · 42.82M shares · 61 new positions · 182 increased · 99 reduced · 44 closed
| Holder | Shares | % outstanding | Chg q/q | Filed |
|---|---|---|---|---|
| Jupiter Topco LLC | 3.42M | 12.27% | +3.42Mnew | Aug 14, 2026 |
| FMR LLC | 2.32M | 8.31% | +156.0K | Aug 13, 2026 |
| BlackRock, Inc. | 2.29M | 8.22% | −32.3K | Aug 7, 2026 |
| Perceptive Advisors LLC | 2.04M | 7.30% | 0 | Aug 14, 2026 |
| Baker Bros. Advisors LP | 1.75M | 6.29% | 0 | Aug 14, 2026 |
| Orbis Allan Gray Ltd | 1.53M | 5.49% | −942.7K | Aug 14, 2026 |
| Vanguard Portfolio Management LLC | 1.34M | 4.79% | +578.4K | Aug 13, 2026 |
| Vanguard Capital Management LLC | 1.24M | 4.43% | +13.4K | Aug 13, 2026 |
Beneficial owners13D/G · 5% or more, as filed
| Holder | % of class | Shares | Form | Filed |
|---|---|---|---|---|
| Janus Henderson Group PLC | 12.30% | 2.76M | 13G | Nov 14, 2025 ↗ |
| Orbis Investment Management Ltd | 8.90% | 2.47M | 13G | May 15, 2026 ↗ |
| FMR LLC | 7.70% | 2.16M | 13G | May 6, 2026 ↗ |
| BlackRock, Inc. | 7.30% | 1.30M | Nov 8, 2024 ↗ | |
| Perceptive Advisors LLC | 7.20% | 2.00M | 13G | Feb 17, 2026 ↗ |
| Baker Bros. Advisors LP | 6.30% | 1.75M | 13G | May 15, 2026 ↗ |
| Vanguard Capital Management | 5.09% | 1.42M | 13G | Apr 30, 2026 ↗ |
InsidersForm 4
| Insider | Role | Shares | % outstanding | Filed |
|---|---|---|---|---|
| Adage Capital Management, L.P. | 10 percent owner | 2.06M | 7.39% | Oct 17, 2025 |
| Marcio Souza | director, officer: Chief Executive Officer | 56.5K | 0.20% | Jul 8, 2026 |
| Timothy Edwin Kelly | officer: Chief Financial Officer | 31.2K | 0.11% | May 19, 2026 |
| Megan Sniecinski | officer: Chief Operating Officer | 28.7K | 0.10% | May 19, 2026 |
| Alex Nemiroff | officer: General Counsel and Secretary | 26.0K | 0.09% | May 19, 2026 |
| Dean J. Mitchell | director | 18.6K | 0.07% | Jun 12, 2026 |
| Lauren Mastrocola | officer: Principal Accounting Officer | 13.6K | 0.05% | May 19, 2026 |
| William D. Young | director | 3.3K | 0.01% | Jun 12, 2026 |
| Stuart A. Arbuckle | director | 2.5K | 0.01% | Jun 12, 2026 |
| Jeffrey B. Kindler | director | 2.5K | 0.01% | Jun 12, 2026 |
3 ten-percent owners hold 2.55M shares by Form 4, outside the officers-and-directors figure above · 4 people have not refiled in the last 18 months (219.6K shares), so they are not in the figure above
Latest trades
| Date | Insider | Type | Shares | Avg price | Owned after |
|---|---|---|---|---|---|
| Jun 24, 2026 | Jill DeSimonedirector | Sale · 12 lots | 11,600 | $311.32 | 2,337 |
| Nov 20, 2025 | Lauren Mastrocolaofficer: Principal Accounting Officer | Sale · 2 lots | 13,600 | $192.08 | 10,442 |
| Nov 20, 2025 | Alex Nemiroffofficer: General Counsel and Secretary | Sale · 4 lots | 25,130 | $193.09 | 20,832 |
| Oct 16, 2025 | Adage Capital Management, L.P.10 percent owner | Sale · 10 lots | 313,910 | $105.76 | 4,421,660 |
CongressHouse and Senate disclosures
Not reported.