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PYXS · NASDAQ · Biotechnology

Pyxis Oncology (PYXS)

Develops MICVO, an investigational ADC for difficult-to-treat solid tumors.

$3.73
Pre-market−0.01 (−0.27%)
At close$3.74(+8.72%)
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Breakdown13F · 13D/G · Form 4

Institutions81 holders · as of Mar 31, 202643.52%27.57M shares
Insiders5 holders · as of Jul 2, 202614.80%9.38M shares
Otherremainder41.68%26.41M shares

63.36M company shares as of Aug 22, 2026 · institutions as of Mar 31, 2026 · holders as of their latest filing

Two share counts disagree (83.41M in the company's Sep 3, 2026 report, 63.36M elsewhere); stakes use the report.

Top shareholders13F · 13D/G · Form 4

HolderStakeSharesEvidence
Lara Sullivan1Insiderdirector, officer: President and CEO
11.91%7.54M13Dfiled Apr 2, 2025 ↗
Pfizer IncInstitution
11.10%7.03M13Fas of Mar 31, 2026
Laurion Capital Management LPInstitution
7.89%5.00M13Fas of Mar 31, 2026
Biotechnology Value Fund L PInstitution
7.28%4.61M13Gfiled Jul 10, 2026 ↗
GordonMD Global Investments LPInstitution
6.51%4.12M13Fas of Mar 31, 2026
Vanguard Capital Management LLCInstitution
3.21%2.03M13Fas of Mar 31, 2026
Pamela Ann ConnealyInsiderofficer: CFO & COO
1.89%1.20MForm 4filed Nov 27, 2024 ↗
Palo Alto Investors LPInstitution
1.59%1.01M13Fas of Mar 31, 2026
683 Capital Management, LLCInstitution
1.41%896,26313Fas of Mar 31, 2026
Renaissance Technologies LLCInstitution
1.40%888,68013Fas of Mar 31, 2026
BlackRock, Inc.Institution
1.25%788,83913Fas of Mar 31, 2026
Geode Capital Management, LLCInstitution
0.94%598,12113Fas of Mar 31, 2026
Jitendra WadhaneInsiderofficer: Prin Fin & Acct Officer
0.81%512,882Form 4filed Mar 25, 2026 ↗
Longaeva Partners L.P.Institution
0.79%503,21413Fas of Mar 31, 2026
Jacobs Levy Equity Management, IncInstitution
0.73%460,99713Fas of Mar 31, 2026
Millennium Management LLCInstitution
0.63%397,62513Fas of Mar 31, 2026
Marshall Wace, LLPInstitution
0.56%354,41713Fas of Mar 31, 2026
Decheng Capital LLCInstitution
0.52%326,81013Fas of Mar 31, 2026
Jane Street Group, LLCInstitution
0.48%304,45913Fas of Mar 31, 2026
Vanguard Fiduciary Trust CoInstitution
0.47%300,89713Fas of Mar 31, 2026
UBS Group AGInstitution
0.40%254,12413Fas of Mar 31, 2026
State Street CorpInstitution
0.39%248,83713Fas of Mar 31, 2026
XTX Topco LtdInstitution
0.32%200,09613Fas of Mar 31, 2026
Healthinvest Partners ABInstitution
0.31%197,03613Fas of Mar 31, 2026
Acadian Asset Management LLCInstitution
0.23%144,25613Fas of Mar 31, 2026
  1. Lara Sullivan's transaction reports restate only vehicles that traded; the 2025 ownership statement (7.54M) is used instead.

13F — a manager's quarterly holdings · 13D/13G — an ownership statement filed at 5% or more · Form 4 — an insider's transaction report

Institutions13F, as of Mar 31, 2026

81 holders · 27.57M shares · 15 new positions · 26 increased · 35 reduced · 15 closed

HolderShares% outstandingChg q/qFiled
Pfizer Inc7.03M11.10%0May 12, 2026
Laurion Capital Management LP5.00M7.89%+200.9KMay 14, 2026
Gordonmd Global Investments LP4.12M6.51%0May 15, 2026
Vanguard Capital Management LLC2.03M3.21%+2.03MnewMay 15, 2026
Palo Alto Investors LP1.01M1.59%−26.9KMay 15, 2026
683 Capital Management, LLC896.3K1.41%+4.4KMay 15, 2026
Renaissance Technologies LLC888.7K1.40%+160.3KMay 14, 2026
BlackRock, Inc.788.8K1.25%+4.8KMay 13, 2026

Ownership statements13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
GordonMD Global Investments LP12.10%10.02M13GJul 2, 2026 ↗
Lara Sullivan, M.D.11.21%7.54M13DApr 2, 2025 ↗
Laurion Capital Management LP7.72%4.80M13GFeb 9, 2026 ↗
Biotechnology Value Fund L P5.50%4.61M13GJul 10, 2026 ↗

Insider tradesForm 4

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Jun 30, 2026
Jakob Dupontdirector
Sale35,000$3.0638,741
Apr 21, 2025
Rachel Humphreydirector
Sale13,896$1.0381,309
Apr 17, 2025
Rachel Humphreydirector
Sale200$0.970095,205
Apr 14, 2025
Rachel Humphreydirector
Sale1,400$0.972795,405

CongressHouse and Senate disclosures

Not reported.