SEPN · NASDAQ · Biotechnology

Septerna

Develops oral GPCR drug candidates using its Native Complex Platform.

$38.91
After-hours close+0.05 (+0.13%)
At close$38.86(−3.98%)

Breakdown13F · Form 4

Institutions 106.01%Insiders 13.55%

A 13F quarter can total more than the shares outstanding — sub-advisers file the same block twice, and a filer's own share count can be a quarter stale. No split is drawn from it.

Shares outstanding 45.08M · Float 18.88M · 41.9% free float

Top shareholders13F · 13D/G · Form 4

HolderShares% outstandingFormFiled
Third Rock Ventures V, L.P. · 10 percent owner8.94M19.84%Form 4Aug 14, 2026
Rajeev Shah7.00M15.80%13DNov 4, 2024
TRV GP V, LLC6.22M13.79%13FAug 10, 2026
Ra Capital Management, L.P. · director, 10 percent owner: 4.78M10.60%Form 4Aug 14, 2026
Driehaus Capital Management LLC4.43M9.83%13FAug 14, 2026

Institutions13F, as of Jun 30, 2026

166 holders · 47.78M shares · 51 new positions · 102 increased · 32 reduced · 17 closed

HolderShares% outstandingChg q/qFiled
Ra Capital Management, L.P.7.00M15.52%0Aug 14, 2026
TRV GP V, LLC6.22M13.79%0Aug 10, 2026
Driehaus Capital Management LLC4.43M9.83%+37.5KAug 14, 2026
TRV GP Vi, LLC4.21M9.34%0Aug 10, 2026
Samsara Biocapital, LLC3.15M6.99%0Aug 14, 2026
Goldman Sachs Group Inc3.06M6.79%+156.3KAug 14, 2026
BlackRock, Inc.1.93M4.29%+109.9KAug 7, 2026
Siren, L.L.C.1.90M4.22%−100.0KAug 13, 2026

Beneficial owners13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
Rajeev Shahincl. Peter Kolchinsky, RA Capital Management, L.P. +1 more15.80%7.00M13DNov 4, 2024
Third Rock Ventures V, L.P.14.00%6.22M13GMay 9, 2025
Driehaus Capital Management LLC10.46%4.66M13GJun 10, 2025
Samsara BioCapital, L.P.incl. Samsara BioCapital GP, LLC, Srinivas Akkaraju6.20%2.77M13GNov 4, 2024
BVF Partners L.P.incl. Biotechnology Value Trading Fund OS LP, BVF I GP LLC +7 more5.50%2.45M13GNov 1, 2024

InsidersForm 4

InsiderRoleShares% outstandingFiled
Third Rock Ventures V, L.P.10 percent owner8.94M19.84%Aug 14, 2026
Ra Capital Management, L.P.director, 10 percent owner: 4.78M10.60%Aug 14, 2026
Jeffrey Finerdirector, officer: CEO and President826.9K1.83%Apr 4, 2025
Elizabeth Bhattofficer: President and COO174.2K0.39%Aug 13, 2026
Alan Ezekowitzdirector117.4K0.26%Mar 10, 2025
Uwe Kleinofficer: SVP, Biological Sciences115.0K0.26%Aug 19, 2025
Daniel D. Longofficer: SVP, Drug Discovery96.4K0.21%Aug 5, 2026
Samira Shaikhlyofficer: Chief People Officer7930.00%Jun 30, 2026

2 ten-percent owners hold 13.15M shares by Form 4 — the 13D/G table above shows those stakes, the figure above counts officers and directors only · 2 people have not refiled in the last 18 months (98.1K shares), so they are not in the figure above

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Aug 12, 2026
Third Rock Ventures V, L.P.10 percent owner
Sale · 2 lots147,200$50.276,068,391
Aug 12, 2026
Ra Capital Management, L.P.director, 10 percent owner:
Sale746,500$42.504,777,415
Aug 11, 2026
Elizabeth Bhattofficer: President and COO
Sale25,000$44.00174,209
Aug 3, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale · 2 lots3,334$34.4796,412
Jul 15, 2026
Elizabeth Bhattofficer: President and COO
Sale4,000$33.99174,209
Jul 1, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale · 2 lots3,333$34.3696,412
Jun 29, 2026
Samira Shaikhlyofficer: Chief People Officer
Sale2,178$35.18793
Jun 22, 2026
Daniel D. Longofficer: SVP, Drug Discovery
Sale · 2 lots15,000$35.5196,412
Jun 12, 2026
Samira Shaikhlyofficer: Chief People Officer
Sale6,250$35.08793
Jun 1, 2026
Samira Shaikhlyofficer: Chief People Officer
Sale · 3 lots5,935$28.93793

CongressHouse and Senate disclosures

Not reported.