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SPRB · NASDAQ · Biotechnology

Spruce Biosciences (SPRB)

Develops an enzyme therapy for Sanfilippo syndrome and a preclinical CAH antibody.

$59.00

Pre-market−0.68 (−1.14%)

At close$59.68(+7.34%)

Watchlist

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Breakdown13F · 13D/G · Form 4

Institutions32 holders · as of Mar 31, 2026	25.74%	739.8K shares
Insiders5 holders · as of Jul 27, 2026	9.77%	280.9K shares
Strategic holders1 holder · as of Oct 8, 2025	0.04%	1.1K shares
Otherremainder	64.45%	1.85M shares

2.87M company shares as of Sep 3, 2026 · institutions as of Mar 31, 2026 · holders as of their latest filing

Top shareholders13F · 13D/G · Form 4

Holder	Stake	Shares	Evidence
Orin HirschmanInsider	8.70%	250,000	13Gfiled Jul 27, 2026 ↗
AWM Investment Company, Inc.Institution	5.11%	146,988	13Gfiled Aug 14, 2026 ↗
Ikarian Capital, LLCInstitution	4.22%	121,356	13Fas of Mar 31, 2026
Millennium Management LLCInstitution	3.89%	111,888	13Fas of Mar 31, 2026
Citadel Advisors LLCInstitution	2.44%	69,999	13Fas of Mar 31, 2026
Adar1 Capital Management, LLCInstitution	2.04%	58,600	13Fas of Mar 31, 2026
Alyeska Investment Group, L.P.Institution	1.80%	51,671	13Fas of Mar 31, 2026
Wellington Management Group LLPInstitution	1.70%	48,796	13Fas of Mar 31, 2026
Boothbay Fund Management, LLCInstitution	1.46%	42,080	13Fas of Mar 31, 2026
Balyasny Asset Management L.P.Institution	1.39%	40,000	13Fas of Mar 31, 2026
Carlyle Group Inc.Institution	1.34%	38,620	13Fas of Mar 31, 2026
Quinn Opportunity Partners LLCInstitution	0.93%	26,810	13Fas of Mar 31, 2026
Exoduspoint Capital Management, LPInstitution	0.77%	22,000	13Fas of Mar 31, 2026
Javier B. SzwarcbergInsiderdirector, officer: CHIEF EXECUTIVE OFFICER	0.67%	19,270	Form 4filed Jul 9, 2026 ↗
Vanguard Capital Management LLCInstitution	0.64%	18,337	13Fas of Mar 31, 2026
BlackRock, Inc.Institution	0.59%	16,938	13Fas of Mar 31, 2026
Geode Capital Management, LLCInstitution	0.45%	12,889	13Fas of Mar 31, 2026
Squadron Capital Management LLCInstitution	0.42%	12,200	13Fas of Mar 31, 2026
Diadema Partners LPInstitution	0.35%	10,000	13Fas of Mar 31, 2026
Samir M. GharibInsiderofficer: PRESIDENT AND CFO	0.29%	8,263	Form 4filed Dec 17, 2025 ↗
Stempoint Capital LPInstitution	0.22%	6,360	13Fas of Mar 31, 2026
Vanguard Fiduciary Trust CoInstitution	0.19%	5,514	13Fas of Mar 31, 2026
Goldman Sachs Group IncInstitution	0.19%	5,506	13Fas of Mar 31, 2026
State Street CorpInstitution	0.19%	5,400	13Fas of Mar 31, 2026
Resolute Capital Asset Partners LLCInstitution	0.14%	4,000	13Fas of Mar 31, 2026

13F — a manager's quarterly holdings · 13D/13G — an ownership statement filed at 5% or more · Form 4 — an insider's transaction report

Institutions13F, as of Mar 31, 2026

32 holders · 739.8K shares · 10 new positions · 16 increased · 6 reduced · 10 closed

Holder	Shares	% outstanding	Chg q/q	Filed
Ikarian Capital, LLC	121.4K	4.22%	0	May 15, 2026
Millennium Management LLC	111.9K	3.89%	+111.9Knew	May 15, 2026
Citadel Advisors LLC	70.0K	2.44%	0	May 15, 2026
Adar1 Capital Management, LLC	58.6K	2.04%	+600	May 18, 2026
Alyeska Investment Group, L.P.	51.7K	1.80%	0	May 15, 2026
Wellington Management Group LLP	48.8K	1.70%	−10.2K	May 15, 2026
Boothbay Fund Management, LLC	42.1K	1.46%	−5.9K	May 15, 2026
Balyasny Asset Management L.P.	40.0K	1.39%	0	May 15, 2026

Ownership statements13D/G · 5% or more, as filed

Holder	% of class	Shares	Form	Filed
Integrated Core Strategies (US) LLC	9.60%	103.0K	13G	Feb 24, 2026 ↗
Orin Hirschman	9.10%	250.0K	13G	Jul 27, 2026 ↗
BlackRock, Inc.	6.80%	187.8K	13G	Jul 30, 2026 ↗
Boone Peter David Mr	6.40%	68.2K	13G	Nov 24, 2025 ↗
ADAR1 Capital Management, LLC	5.40%	58.0K	13G	Feb 17, 2026 ↗
AWM Investment Company, Inc.	5.10%	147.0K	13G	Aug 14, 2026 ↗
Citadel Advisors LLC	5.10%	70.0K	13G	May 15, 2026 ↗

Insider tradesForm 4

Latest trades

Date	Insider	Type	Shares	Avg price	Owned after
Oct 6, 2025	Parkman Healthcare Partners LLC10 percent owner	Sale · 2 lots	257	$19.14	1,050
Oct 6, 2025	Parkman Healthcare Partners LLC10 percent owner	Purchase	256	$17.91	1,307

CongressHouse and Senate disclosures

Not reported.