SPRO · NASDAQ · Biotechnology

Spero Therapeutics (SPRO)

Develops SP001 while retaining economics linked to GSK-marketed Utebzi.

$1.22
At close+0.02 (+1.67%)

Breakdown13F · 13D/G · Form 4

Institutions55 holders · as of Mar 31, 202635.45%20.64M shares
Insiders12 holders · as of Aug 6, 20268.49%4.94M shares
Otherremainder56.06%32.65M shares

58.23M company shares as of Sep 3, 2026 · institutions as of Mar 31, 2026 · holders as of their latest filing

Top shareholders13F · 13D/G · Form 4

HolderStakeSharesEvidence
GSK PLCInstitution
15.78%9.19M13Fas of Mar 31, 2026
Pfizer IncInstitution
4.06%2.36M13Fas of Mar 31, 2026
Vanguard Capital Management LLCInstitution
3.09%1.80M13Fas of Mar 31, 2026
Sath ShuklaInsiderofficer: CEO & President
2.98%1.74MForm 4filed Feb 5, 2025
Renaissance Technologies LLCInstitution
2.04%1.19M13Fas of Mar 31, 2026
Esther RajaveluInsiderofficer: See Remarks
1.69%986,851Form 4filed May 6, 2026
Alphabet Inc.Institution
1.53%889,97913Fas of Mar 31, 2026
Two Sigma Investments, LPInstitution
1.52%885,63113Fas of Mar 31, 2026
Timothy KeutzerInsiderofficer: Chief Operating Officer
1.28%742,506Form 4filed Feb 9, 2026
Ankit MahadeviaInsiderdirector
1.21%703,294Form 4filed Sep 3, 2025
Geode Capital Management, LLCInstitution
0.89%519,92213Fas of Mar 31, 2026
BlackRock, Inc.Institution
0.74%433,20213Fas of Mar 31, 2026
Anson Funds Management LPInstitution
0.72%421,95613Fas of Mar 31, 2026
Citadel Advisors LLCInstitution
0.65%376,45813Fas of Mar 31, 2026
Susquehanna International Group, LLPInstitution
0.57%333,11513Fas of Mar 31, 2026
Gsa Capital Partners LLPInstitution
0.48%278,30413Fas of Mar 31, 2026
Vanguard Fiduciary Trust CoInstitution
0.45%264,11513Fas of Mar 31, 2026
State Street CorpInstitution
0.37%214,75113Fas of Mar 31, 2026
Ionic Capital Management LLCInstitution
0.34%195,93913Fas of Mar 31, 2026
Squarepoint Ops LLCInstitution
0.33%194,30113Fas of Mar 31, 2026
Debra ZackInsiderofficer: Chief Medical Officer
0.28%162,311Form 4filed Aug 6, 2026
Marshall Wace, LLPInstitution
0.27%157,07213Fas of Mar 31, 2026
Northern Trust CorpInstitution
0.21%120,98413Fas of Mar 31, 2026
Bridgeway Capital Management, LLCInstitution
0.20%114,80013Fas of Mar 31, 2026
Jane Street Group, LLCInstitution
0.18%106,34513Fas of Mar 31, 2026

13F — a manager's quarterly holdings · Form 4 — an insider's transaction report

Institutions13F, as of Mar 31, 2026

55 holders · 20.64M shares · 8 new positions · 20 increased · 11 reduced · 14 closed

HolderShares% outstandingChg q/qFiled
GSK PLC9.19M15.78%0May 14, 2026
Pfizer Inc2.36M4.06%0May 12, 2026
Vanguard Capital Management LLC1.80M3.09%+1.80MnewMay 15, 2026
Renaissance Technologies LLC1.19M2.04%−90.3KMay 14, 2026
Alphabet Inc.890.0K1.53%0May 8, 2026
Two Sigma Investments, LP885.6K1.52%+513.1KMay 15, 2026
Geode Capital Management, LLC519.9K0.89%−9.3KMay 15, 2026
BlackRock, Inc.433.2K0.74%−414May 13, 2026

Ownership statements13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
GSK PLC16.40%9.19M13DMar 28, 2025

Insider tradesForm 4

Latest trades

DateInsiderTypeSharesAvg priceOwned after
May 4, 2026
Esther Rajaveluofficer: See Remarks
Sale25,240$2.51986,851
Feb 6, 2026
Timothy Keutzerofficer: Chief Operating Officer
Sale18,652$2.36742,506
Feb 6, 2026
Esther Rajaveluofficer: See Remarks
Sale · 2 lots87,917$2.361,012,091
Feb 4, 2026
Timothy Keutzerofficer: Chief Operating Officer
Sale3,471$2.24761,158
Feb 3, 2026
Timothy Keutzerofficer: Chief Operating Officer
Sale24,224$2.14764,629
Feb 2, 2026
Timothy Keutzerofficer: Chief Operating Officer
Sale18,891$2.20788,853
Feb 2, 2026
Esther Rajaveluofficer: See Remarks
Sale18,442$2.201,100,008
Nov 7, 2025
Esther Rajaveluofficer: See Remarks
Sale40,270$2.37869,450
Aug 28, 2025
Timothy Keutzerofficer: Chief Operating Officer
Sale1,695$1.97739,744
Aug 28, 2025
Ankit Mahadeviadirector
Sale6,572$1.97703,294

CongressHouse and Senate disclosures

Not reported.