Upstream Bio
Developing verekitug, a TSLP-receptor antibody for severe respiratory diseases.
$6.69
After-hours close+0.01 (+0.15%)
At close$6.68(−1.62%)
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Breakdown13F · Form 4
Institutions 82.48%Insiders —
Shares outstanding 54.42M · Float 20.08M · 36.9% free float
Institutions13F, as of Mar 31, 2026
145 holders · 44.89M shares · 46 new positions · 95 increased · 35 reduced · 40 closed
| Holder | Shares | % outstanding | Chg q/q | Filed |
|---|---|---|---|---|
| FMR LLC | 8.10M | 14.89% | +583.4K | May 15, 2026 |
| Orbimed Advisors LLC | 5.69M | 10.46% | 0 | May 15, 2026 |
| BlackRock, Inc. | 3.37M | 6.19% | +26.2K | May 13, 2026 |
| Decheng Capital LLC | 2.72M | 5.01% | −418.2K | May 13, 2026 |
| Enavate Sciences GP, LLC | 2.46M | 4.52% | 0 | May 15, 2026 |
| Vanguard Capital Management LLC | 1.87M | 3.44% | +1.87Mnew | May 15, 2026 |
| Y-Intercept (Hong Kong) Ltd | 1.00M | 1.84% | +954.1K | Apr 27, 2026 |
| Federated Hermes, Inc. | 979.8K | 1.80% | +979.3K | May 11, 2026 |
Beneficial owners13D/G · 5% or more, as filed
| Holder | % of class | Shares | Form | Filed |
|---|---|---|---|---|
| FMR LLC | 14.80% | 7.94M | 13G | Aug 6, 2025 ↗ |
| AI Upstream LLCincl. Access Industries Holdings LLC, Access Industries Management, LLC +2 more | 10.70% | 5.49M | 13D | Oct 22, 2024 ↗ |
| OrbiMed Advisors LLCincl. OrbiMed Advisors Israel II Limited, OrbiMed Israel GP II, L.P. +1 more | 8.90% | 4.55M | 13D | Oct 17, 2024 ↗ |
| Norges Bank | 5.30% | 2.88M | 13G | Oct 24, 2025 ↗ |
| BlackRock, Inc. | 5.20% | 2.81M | 13G | Jul 30, 2026 ↗ |
| Decheng Capital Global Life Sciences Fund IV, L.P. | 5.00% | 2.72M | 13G | May 15, 2026 ↗ |
InsidersForm 4
Latest trades
Nothing filed in the last 12 months.
CongressHouse and Senate disclosures
Not reported.