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LXRX · NASDAQ · Biotechnology

Lexicon Pharmaceuticals (LXRX)

Develops medicines for heart failure, cardiometabolic conditions, and neuropathic pain.

$2.25

Pre-market0.00 (0.00%)

At close$2.25(+2.74%)

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Breakdown13F · 13D/G · Form 4

Institutions155 holders · as of Jun 30, 2026 · largest filers plus last quarter's tail	≈ 82.33%	366.31M shares
Insiders17 holders · as of Jun 4, 2026	31.37%	139.58M shares
Strategic holders2 holders · as of Feb 12, 2026	37.12%	165.17M shares
Adds to	150.82%

444.96M company shares as of Sep 3, 2026 · institutions as of Jun 30, 2026 · holders as of their latest filing

This quarter's institutional total failed a plausibility check; shown: the largest filers plus last quarter's remainder.

These groups come from separate filings that can overlap, so they add to 150.82%; nothing is left for Other.

Top shareholders13F · 13D/G · Form 4

Holder	Stake	Shares	Evidence
Artal Group S.A.Institution	39.36%	175.16M	13Fas of Jun 30, 2026
Invus Global Management, LLCStrategicdirector, 10 percent owner	36.78%	163.64M	Form 4filed Feb 4, 2026 ↗
Participations S.a r.l. Artal¹Insiderdirector, 10 percent owner	30.61%	136.18M	Form 4filed May 8, 2026 ↗
FMR LLCInstitution	11.64%	51.78M	13Fas of Jun 30, 2026
Siren, L.L.C.Institution	9.96%	44.30M	13Fas of Jun 30, 2026
Sessa Capital Im, L.P.Institution	4.26%	18.96M	13Fas of Jun 30, 2026
BlackRock, Inc.Institution	3.90%	17.35M	13Fas of Jun 30, 2026
Vanguard Capital Management LLCInstitution	2.23%	9.90M	13Fas of Jun 30, 2026
Point72 Asset Management, L.P.Institution	1.85%	8.25M	13Fas of Jun 30, 2026
Geode Capital Management, LLCInstitution	1.40%	6.24M	13Fas of Jun 30, 2026
State Street CorpInstitution	1.11%	4.92M	13Fas of Jun 30, 2026
Vanguard Portfolio Management LLCInstitution	0.53%	2.36M	13Fas of Jun 30, 2026
Northern Trust CorpInstitution	0.44%	1.97M	13Fas of Jun 30, 2026
Charles Schwab Investment Management IncInstitution	0.44%	1.96M	13Fas of Jun 30, 2026
Sixth Street Partners Management Company, L.P.Institution	0.44%	1.96M	13Fas of Jun 30, 2026
Vanguard Fiduciary Trust CoInstitution	0.37%	1.63M	13Fas of Jun 30, 2026
Citadel Advisors LLCInstitution	0.36%	1.60M	13Fas of Jun 30, 2026
Avicenna Life Sci Master Fund LPStrategicdirector, 10 percent owner	0.35%	1.54M	Form 4filed Feb 12, 2026 ↗
Ishara Investments LPInstitution	0.29%	1.27M	13Fas of Jun 30, 2026
Millennium Management LLCInstitution	0.25%	1.13M	13Fas of Jun 30, 2026
Renaissance Technologies LLCInstitution	0.25%	1.13M	13Fas of Jun 30, 2026
Mackenzie Financial CorpInstitution	0.22%	963,354	13Fas of Jun 30, 2026
Adar1 Capital Management, LLCInstitution	0.17%	750,000	13Fas of Jun 30, 2026
Susquehanna International Group, LLPInstitution	0.16%	696,776	13Fas of Jun 30, 2026
Acadian Asset Management LLCInstitution	0.16%	696,617	13Fas of Jun 30, 2026

Participations S.a r.l. Artal reports a block also reported by Artal Group S.A.; it is counted once, under Artal Group S.A.

13F — a manager's quarterly holdings · Form 4 — an insider's transaction report

Institutions13F, as of Jun 30, 2026

155 holders · 366.31M shares · 47 new positions · 84 increased · 36 reduced · 31 closed

Holder	Shares	% outstanding	Chg q/q	Filed
Artal Group S.A.	175.16M	39.36%	+20.42M	Aug 13, 2026
FMR LLC	51.78M	11.64%	+6.73M	Aug 13, 2026
Siren, L.L.C.	44.30M	9.96%	0	Aug 13, 2026
Sessa Capital Im, L.P.	18.96M	4.26%	+1.05M	Aug 14, 2026
BlackRock, Inc.	17.35M	3.90%	+14.03M	Aug 7, 2026
Vanguard Capital Management LLC	9.90M	2.23%	+382.0K	Aug 13, 2026
Point72 Asset Management, L.P.	8.25M	1.85%	+436.7K	Aug 14, 2026
Geode Capital Management, LLC	6.24M	1.40%	+3.08M	Aug 12, 2026

Ownership statements13D/G · 5% or more, as filed

Holder	% of class	Shares	Form	Filed
Stichting Administratiekantoor Westendincl. Raymond Debbane, Amaury Wittouck +15 more	39.40%	175.16M	13D	May 8, 2026 ↗
FMR LLC	10.50%	38.14M	13G	Jul 8, 2025 ↗

Insider tradesForm 4

Latest trades

Date	Insider	Type	Shares	Avg price	Owned after
Feb 25, 2026	Raymond Debbanedirector	Purchase	2,000	$1.49	1,906,186
Feb 23, 2026	Raymond Debbanedirector	Purchase	100,000	$1.47	1,904,186
Feb 19, 2026	Raymond Debbanedirector	Purchase	50,000	$1.44	1,704,186
Feb 20, 2026	Raymond Debbanedirector	Purchase	100,000	$1.48	1,804,186
Feb 13, 2026	Raymond Debbanedirector	Purchase	57,952	$1.31	1,443,641
Feb 17, 2026	Raymond Debbanedirector	Purchase	76,857	$1.31	1,520,498
Feb 18, 2026	Raymond Debbanedirector	Purchase	133,688	$1.32	1,654,186
Feb 2, 2026	Invus Global Management, LLCdirector, 10 percent owner:	Purchase	1,538,462	$1.30	1,538,462

CongressHouse and Senate disclosures

Not reported.