Mereo BioPharma Group (ADR) (MREO)
Advances acquired rare-disease drug candidates through clinical development and partnerships.
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Develops setrusumab for osteogenesis imperfecta and alvelestat for severe alpha-1 antitrypsin deficiency-associated lung disease. Clinically advanced assets are acquired and advanced through partnerships, with setrusumab commercial rights retained in Europe and the U.K.
Develops setrusumab for osteogenesis imperfecta and alvelestat for severe alpha-1 antitrypsin deficiency-associated lung disease. Both programs reflect an asset-selection model: clinically advanced candidates are acquired after larger drugmakers deprioritize them, then advanced through scientific, commercial, and collaboration capabilities.
Setrusumab is partnered with Ultragenyx, while commercial rights in Europe and the U.K. are retained. Other candidates came from Novartis, AstraZeneca, and the OncoMed transaction, leaving a portfolio of partnered or partner-seeking programs rather than a discovery-led platform.
Clinical-trial enrollment, potential product-market size, key executives, and continued Nasdaq listing compliance shape execution. Certain pre-commercial and manufacturing activities for setrusumab were curtailed or delayed after top-line trial data.
Company facts
Target rangeAs of Sep 2, 2026
Latest analyst notes
| Date | Firm | Action | Prior rating | Rating | Prior target | Target |
|---|---|---|---|---|---|---|
| Aug 19, 2026 | JP Morgan | Downgrade | Neutral | Underweight | ||
| Mar 23, 2026 | JP Morgan | Downgrade | Overweight | Neutral | ||
| Dec 30, 2025 | Jefferies | Downgrade | Buy | Hold | $0.50 | |
| Dec 29, 2025 | Robert W. Baird | Target | $8 | $1 | ||
| Dec 29, 2025 | BTIG | Reiterate | Buy | $6 | $1 |
EPSReportedEstimate
RevenueReportedEstimate
Balance sheet, Jun 30, 2026Cash & short-term investments $30.1M · Total debt $1.0M · Total assets $34.7M · Shareholders' equity $28.7M
- Revenue
- $0
- Operating income
- −$7.0M
- Net income
- −$7.0M
No dividends on record.
| Institutions67 holders · as of Mar 31, 2026 | 47.20% | 75.38M ADS | |
| Insiders5 holders · as of Sep 16, 2024 | 0.78% | 1.25M ADS | |
| Strategic holders1 holder · as of Feb 11, 2022 | 1.18% | 1.88M ADS | |
| Otherremainder | 50.84% | 81.18M ADS |
159.69M ADS (1 ADS = 5 ordinary shares) as of Sep 3, 2026 · institutions as of Mar 31, 2026 · holders as of their latest filing
Top shareholders13F · 13D/G · Form 4
| Holder | Stake | Shares | Evidence |
|---|---|---|---|
Rubric Capital Management LPInstitution | 9.59% | 15.31M ADS | 13Fas of Mar 31, 2026 |
Ecor1 Capital, LLCInstitution | 8.37% | 13.37M ADS | 13Fas of Mar 31, 2026 |
683 Capital Management, LLCInstitution | 7.51% | 12.00M ADS | 13Fas of Mar 31, 2026 |
Bank of America Corp /DE/Institution | 5.13% | 8.20M ADS | 13Fas of Mar 31, 2026 |
Defilade Capital Management, L.P.Institution | 4.73% | 7.56M ADS | 13Fas of Mar 31, 2026 |
| See all 25 → | |||
13F — a manager's quarterly holdings
Insider tradesForm 4
No open-market trades in the last 12 months.
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ComparePre-market
| Company | Price | Change | |||||
|---|---|---|---|---|---|---|---|
| Mereo BioPharma Group (ADR) | $0.2651 | −0.75% | $42.7M | — | — | — | — |
| Amgen | $443.00 | +0.04% | $239.00B | 27.5 | 18.9 | 6.3 | +9.7% |
| Grifols (ADR) | $7.89 | +0.66% | $6.62B | 10.1 | — | 0.9 | −4.2% |
| Takeda (ADR) | $18.73 | +1.55% | $58.65B | 51.2 | 56.7 | 2.0 | +5.8% |
| Kamada | $8.20 | −2.28% | $484.6M | 22.2 | 16.6 | 2.5 | +22.7% |
| Median | 24.8 | 18.9 | 2.3 | +7.7% |