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OBIO · NASDAQ · Biotechnology

Orchestra BioMed (OBIO)

Develops partnership-enabled device therapies for hypertension and artery disease.

$4.95

At close+0.05 (+1.02%)

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Breakdown13F · 13D/G · Form 4

Institutions66 holders · as of Mar 31, 2026	38.42%	23.09M shares
Insiders10 holders · as of Sep 2, 2026	6.13%	3.68M shares
Strategic holders2 holders · as of Feb 27, 2026	21.51%	12.93M shares
Otherremainder	33.94%	20.40M shares

60.11M company shares as of Sep 3, 2026 · institutions as of Mar 31, 2026 · holders as of their latest filing

Top shareholders13F · 13D/G · Form 4

Holder	Stake	Shares	Evidence
Medtronic plc^1,2Strategic10 percent owner	16.77%	10.08M	13Gfiled Feb 27, 2026 ↗
RTW Investments, LPInstitution	13.82%	8.31M	13Fas of Mar 31, 2026
Perceptive Advisors LLCInstitution	8.38%	5.04M	13Fas of Mar 31, 2026
Tasso Partners, LLCStrategic	4.74%	2.85M	13Gfiled Nov 19, 2025 ↗
Vanguard Capital Management LLCInstitution	3.67%	2.20M	13Fas of Mar 31, 2026
David P. HochmanInsiderdirector, officer: See Remarks	2.49%	1.50M	Form 4filed Jun 12, 2026 ↗
Darren ShermanInsiderdirector, officer: See Remarks	1.89%	1.14M	Form 4filed Sep 2, 2026 ↗
Alyeska Investment Group, L.P.Institution	1.66%	1.00M	13Fas of Mar 31, 2026
Propel Bio Management, LLCInstitution	1.49%	896,701	13Fas of Mar 31, 2026
Millennium Management LLCInstitution	1.17%	702,543	13Fas of Mar 31, 2026
BlackRock, Inc.Institution	1.06%	635,714	13Fas of Mar 31, 2026
Andrew Lawrence TaylorInsiderofficer: Chief Financial Officer	0.98%	589,989	Form 4filed Aug 28, 2026 ↗
Geode Capital Management, LLCInstitution	0.81%	485,492	13Fas of Mar 31, 2026
Affinity Asset Advisors, LLCInstitution	0.67%	402,550	13Fas of Mar 31, 2026
Charles Schwab Investment Management IncInstitution	0.44%	265,499	13Fas of Mar 31, 2026
Knott David M JrInstitution	0.42%	253,651	13Fas of Mar 31, 2026
Vanguard Fiduciary Trust CoInstitution	0.39%	235,214	13Fas of Mar 31, 2026
Simplify Asset Management Inc.Institution	0.37%	219,387	13Fas of Mar 31, 2026
Marshall Wace, LLPInstitution	0.31%	188,484	13Fas of Mar 31, 2026
683 Capital Management, LLCInstitution	0.31%	185,000	13Fas of Mar 31, 2026
State Street CorpInstitution	0.28%	169,410	13Fas of Mar 31, 2026
Goldman Sachs Group IncInstitution	0.26%	155,242	13Fas of Mar 31, 2026
Dafna Capital Management LLCInstitution	0.21%	126,841	13Fas of Mar 31, 2026
Northern Trust CorpInstitution	0.20%	118,274	13Fas of Mar 31, 2026
Jason AryehInsiderdirector	0.20%	118,118	Form 4filed May 20, 2026 ↗

Medtronic plc's transaction reports restate only vehicles that traded; the 2026 ownership statement (10.08M) is used instead.
Medtronic plc reports a block also reported by Perceptive Advisors LLC; it is counted once, under Perceptive Advisors LLC.

13F — a manager's quarterly holdings · 13D/13G — an ownership statement filed at 5% or more · Form 4 — an insider's transaction report

Institutions13F, as of Mar 31, 2026

66 holders · 23.09M shares · 19 new positions · 43 increased · 13 reduced · 17 closed

Holder	Shares	% outstanding	Chg q/q	Filed
RTW Investments, LP	8.31M	13.82%	0	May 15, 2026
Perceptive Advisors LLC	5.04M	8.38%	−89.4K	May 29, 2026
Vanguard Capital Management LLC	2.20M	3.67%	+2.20Mnew	May 15, 2026
Alyeska Investment Group, L.P.	1.00M	1.66%	0	May 15, 2026
Propel Bio Management, LLC	896.7K	1.49%	+896.7Knew	May 14, 2026
Millennium Management LLC	702.5K	1.17%	+459.1K	May 15, 2026
BlackRock, Inc.	635.7K	1.06%	+4.8K	May 13, 2026
Geode Capital Management, LLC	485.5K	0.81%	+12.1K	May 15, 2026

Ownership statements13D/G · 5% or more, as filed

Holder	% of class	Shares	Form	Filed
Roderick Wongincl. RTW Innovation Master Fund, Ltd., RTW Investments, LP +1 more	19.20%	11.94M	13D	Apr 29, 2026 ↗
Medtronic plc	17.80%	10.08M	13G	Feb 27, 2026 ↗
Perceptive Advisors LLC	9.99%	5.68M	13G	Nov 14, 2025 ↗
BlackRock, Inc.	5.10%	1.94M		Nov 8, 2024 ↗
Tasso Partners, LLC	5.00%	2.85M	13G	Nov 19, 2025 ↗

Insider tradesForm 4

Latest trades

Date	Insider	Type	Shares	Avg price	Owned after
Sep 1, 2026	Darren Shermandirector, officer: See Remarks	Sale	15,000	$4.94	1,134,402
Aug 26, 2026	Darren Shermandirector, officer: See Remarks	Purchase	2,000	$5.33	2,000
Aug 3, 2026	Darren Shermandirector, officer: See Remarks	Sale	15,000	$4.09	1,154,327
Jul 1, 2026	Darren Shermandirector, officer: See Remarks	Sale	15,000	$4.27	1,169,327
Jun 1, 2026	Darren Shermandirector, officer: See Remarks	Sale	15,000	$3.87	1,184,327
Jun 1, 2026	David P. Hochmandirector, officer: See Remarks	Purchase	5,000	$3.83	1,064,029
May 18, 2026	Jason Aryehdirector	Purchase	665	$3.75	118,118
May 15, 2026	David P. Hochmandirector, officer: See Remarks	Purchase	5,000	$3.77	1,059,029
May 15, 2026	Jason Aryehdirector	Purchase	8,971	$3.90	117,453
May 14, 2026	Eric S. Faindirector	Purchase	20,000	$4.13	91,709

CongressHouse and Senate disclosures

Not reported.