TYRA · NASDAQ · Biotechnology

Tyra Biosciences

Developer of oral FGFR-targeted medicines for urothelial cancers and achondroplasia.

$24.94
After-hours close−0.05 (−0.22%)
At close$25.00(−4.34%)

Breakdown13F · Form 4

Institutions 117.95%Insiders 26.51%

A 13F quarter can total more than the shares outstanding — sub-advisers file the same block twice, and a filer's own share count can be a quarter stale. No split is drawn from it.

Shares outstanding 59.66M · Float 44.33M · 74.3% free float

Top shareholders13F · 13D/G · Form 4

HolderShares% outstandingFormFiled
Ra Capital Management, L.P.12.20M20.45%13FAug 14, 2026
FMR LLC8.92M14.95%13FAug 13, 2026
Jupiter Topco LLC4.35M7.30%13FAug 14, 2026
Janus Henderson Group PLC3.89M7.20%13GMay 15, 2026
Alta Partners Management Company, L.P.3.82M6.41%13FJul 22, 2026

Institutions13F, as of Jun 30, 2026

177 holders · 70.37M shares · 36 new positions · 111 increased · 43 reduced · 25 closed

HolderShares% outstandingChg q/qFiled
Ra Capital Management, L.P.12.20M20.45%0Aug 14, 2026
FMR LLC8.92M14.95%+1.17MAug 13, 2026
Jupiter Topco LLC4.35M7.30%+4.35MnewAug 14, 2026
Alta Partners Management Company, L.P.3.82M6.41%0Jul 22, 2026
Nextech Invest, Ltd.3.55M5.96%−502.3KAug 14, 2026
TCG Crossover Management, LLC3.25M5.45%0Aug 14, 2026
BlackRock, Inc.3.03M5.08%+814.0KAug 7, 2026
Price T Rowe Associates Inc /MD/2.78M4.66%+1.80MAug 14, 2026

Beneficial owners13D/G · 5% or more, as filed

Holder% of classSharesFormFiled
RA Capital Management, L.P.incl. Peter Kolchinsky, Rajeev Shah +1 more21.20%12.27M13DMar 6, 2026
FMR LLC14.40%7.75M13GApr 7, 2026
Janus Henderson Group PLC7.20%3.89M13GMay 15, 2026
TCG Crossover GP I, LLC5.70%2.90M13GMar 6, 2025
Commodore Capital LP5.20%2.75M13GMay 14, 2025
BlackRock, Inc.5.00%2.98M13GJul 30, 2026

InsidersForm 4

InsiderRoleShares% outstandingFiled
Ra Capital Management, L.P.director, 10 percent owner: 10.26M17.20%Jun 16, 2025
Robert J. Moredirector3.82M6.41%Dec 19, 2025
Todd Harrisdirector, officer: President and CEO1.44M2.41%May 7, 2026
Daniel Bensenofficer: Chief Discovery Officer147.0K0.25%Feb 13, 2026
Yuliya Ruebofficer: Vice President, Finance (PAO)43.4K0.07%May 7, 2026
Alan Fuhrmanofficer: Chief Financial Officer36.2K0.06%May 7, 2026
Gilla Kaplandirector28.2K0.05%Mar 27, 2026
Douglas J. Warnerofficer: Chief Medical Officer25.0K0.04%May 7, 2026
Bhavesh Asharofficer: Chief Operating Officer15.0K0.03%May 7, 2026

4 ten-percent owners hold 5.18M shares by Form 4 — the 13D/G table above shows those stakes, the figure above counts officers and directors only · 10 people have not refiled in the last 18 months (6.00M shares), so they are not in the figure above

Latest trades

DateInsiderTypeSharesAvg priceOwned after
Mar 25, 2026
Gilla Kaplandirector
Sale14,295$36.9728,231
Feb 12, 2026
Daniel Bensenofficer: Chief Discovery Officer
Sale · 2 lots8,000$32.87146,981
Jan 12, 2026
Daniel Bensenofficer: Chief Discovery Officer
Sale · 2 lots8,000$28.52154,981
Dec 19, 2025
Robert J. Moredirector
Sale10,000$25.003,823,425
Dec 12, 2025
Daniel Bensenofficer: Chief Discovery Officer
Sale8,000$22.64162,981
Nov 21, 2025
Robert J. Moredirector
Sale246,871$20.253,833,425
Nov 19, 2025
Daniel Bensenofficer: Chief Operating Officer
Sale49,956$16.32170,981
Nov 18, 2025
Daniel Bensenofficer: Chief Operating Officer
Sale75,633$16.07220,937
Nov 17, 2025
Daniel Bensenofficer: Chief Operating Officer
Sale · 2 lots20,072$16.18296,570
Nov 14, 2025
Daniel Bensenofficer: Chief Operating Officer
Sale110,228$16.02316,642

CongressHouse and Senate disclosures

Not reported.