AYTU · NASDAQ · Drug Manufacturers - Specialty & Generic

Aytu BioPharma

Commercializer of prescription medicines for depression, ADHD, and pediatric conditions.

$2.25
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At close$2.25(+0.45%)
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Aytu BioPharma, Inc.AYTUHealth Care

Sells prescription medicines for adult depression, ADHD, and pediatric conditions through its commercial organization and third-party channels. The business is a single U.S.-focused segment shifting attention toward licensed EXXUA while its ADHD portfolio remains its main revenue base.

Commercializes prescription medicines for central-nervous-system conditions, centering on EXXUA for adult major depressive disorder and the ADHD products Adzenys XR-ODT and Cotempla XR-ODT. A smaller pediatric portfolio includes Karbinal ER and Poly-Vi-Flor and Tri-Vi-Flor. Products reach U.S. customers through an internal commercial organization, wholesalers, distributors, pharmacies, and RxConnect network pharmacies; the ADHD products also have partners pursuing approval and commercialization in Canada, Israel, and the Palestinian Authority.

Operates as one reportable prescription-pharmaceutical segment after divesting Consumer Health and suspending clinical-development programs. Commercial activity increasingly focuses on licensed EXXUA, while legacy ADHD products remain the primary revenue base and face generic competition. Revenue depends on third-party manufacturing and distribution, controlled-substance rules for the ADHD portfolio, payor access, and the EXXUA licensing agreement.

Company facts

CEOJoshua R. Disbrow
ListedOct 20, 2017
ExchangeNASDAQ
HeadquartersDenver, CO
CountryUnited States
Employees83
CIK0001385818
ISINUS0547548588

Key statistics

Market cap$24.1M
EPS (ttm)−$4.58
P/E (ttm)−0.4916
ROE-148.9%
P/B0.6730
P/S0.4267
Dividend yield
Beta0.86vs XLV 0.36

Year to date −18.8% · Average volume (30d) 28.9K

Analysts

No analyst consensus on record.

Earnings

EPS

Estimate−$0.22
ReportedDue Sep 22, 2026

Revenue

Estimate$17.2M
ReportedDue Sep 22, 2026

History

Report dateEPS estEPSSurpriseRevenue estRevenueSurpriseNext session
May 13, 2026Q3 FY26−$0.31−$0.53−71.0%$12.1M$12.4M+3.0%+0.89%
Feb 3, 2026Q2 FY26−$0.26−$1.05−303.8%$12.2M$15.2M+24.9%−10.31%
Nov 13, 2025Q1 FY26−$0.06−$0.08−33.3%$12.6M$13.9M+10.2%+1.46%
Sep 23, 2025Q4 FY25−$0.02−$0.26−1,200.0%$17.9M$15.1M−15.5%−17.93%
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Financial highlights

12 quartersQ2 FY25Q3 FY25Q4 FY25Q1 FY26Q2 FY26Q3 FY26
Revenue$16.2M$18.5M$15.1M$13.9M$15.2M$12.4M
Gross profit$10.8M$12.8M$10.3M$9.2M$9.1M$6.8M
Operating income−$1.7M$2.4M−$7.6M−$1.5M−$2.0M−$4.1M
Net income$788.0K$4.0M−$19.8M$2.0M−$10.6M−$5.6M
Diluted EPS−$0.26$0.21−$2.92−$0.08−$1.05−$0.53
Gross margin66.5%69.4%67.8%66.1%60.0%55.1%
Operating margin-10.4%13.1%-50.4%-10.8%-13.0%-32.7%

Fiscal years (4-quarter sums)FY21 $65.6M · FY22 $96.7M · FY23 $107.4M · FY24 $68.6M · FY25 $66.4M

Balance sheet, Mar 31, 2026Cash & short-term investments $26.7M · Total debt $22.9M · Total assets $111.7M · Shareholders' equity $35.1M

Dividends

No dividends on record.

Ownership

Institutions 36.83%3.95M sharesInsiders 5.21%558.9K sharesOther 57.96%6.22M shares

Shares outstanding 10.73M · Float 9.77M · 91.0% free float

Top shareholders13F · 13D/G · Form 4

HolderShares% outstandingFormFiled
Nantahala Capital Management, LLC1.09M10.13%13FMay 15, 2026
Lytton Laurence W1.07M9.99%13GFeb 17, 2026
Stonepine Capital Management, LLC792.3K7.38%13FMay 14, 2026
Awm Investment Company, Inc.619.6K5.77%13FMay 15, 2026
Diadema Partners LP353.1K3.29%13FMay 15, 2026

Insider tradesForm 4

No open-market trades in the last 12 months.

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Peers

  • Teva (ADR)

    Immediate generic pressure on the ADHD XR-ODT franchise.

  • Takeda (ADR)

    Branded ADHD and MDD alternatives across both commercial priorities.

  • Axsome Therapeutics

    Fast-growing branded oral MDD alternative with broad payer reach.

  • Johnson & Johnson

    Established long-acting methylphenidate brand for ADHD prescribers.

  • Amneal Pharmaceuticals

    Low-cost generic extended-release stimulant pressure in ADHD.

  • AbbVie

    Adjunctive MDD therapy for antidepressant partial responders.

CompareAfter-hours close

CompanyPriceChange
Aytu BioPharma$2.250.00%$24.1M0.4−32.7%
Teva (ADR)$36.30−0.36%$42.44B60.712.92.5−0.8%
Takeda (ADR)$18.49+2.53%$57.37B51.053.72.0+5.8%
Axsome Therapeutics$199.00−0.04%$10.24B1,707.613.2+44.2%
Johnson & Johnson$268.40+0.13%$645.95B31.122.46.6+6.6%
Amneal Pharmaceuticals$17.540.00%$5.60B36.016.91.8+9.9%
AbbVie$255.80+0.13%$451.38B72.016.87.0+10.2%
Median51.019.64.5+8.2%